Cholesterol, insoluble molecule, circulates associated with lipoproteins (HDL, LDL and VLDL). LDL (Low Density Lipoprotein) come from VLDL (Very Low Density Lipoprotein) hydrolysis by different lipolitic enzymes. LDL, which transport approximatively 60% of total plasmatic cholesterol, are mainly taken up through specific receptors by extrahepatic and hepatic tissues.
A positive association exists between the incidence of coronary heart disease and LDL cholesterol. LDL are atherogen lipoproteins:
LDL cholesterol increase is a major cause of apparition and evolution of atherosclerosis, in particular coronary atherosclerosis.
Therefore, the treatment of elevated LDL cholesterol is the primary target of cholesterol-lowering therapy.
An increase in LDL cholesterol may be seen in different pathological states including hyperlipoproteinemia types IIa and IIb, premature coronary heart diseases, hyperlipoproteinemia due to hepatic or renal disorder, to hypothyroidism, diabetes.