Alkaline phosphatase (ALP) corresponds to a group of phosphatases that display maximum activity at alkaline pH. ALP is widely distributed in liver, osteoblasts, intestinal epithelium, kidneys, and placenta.
The rate of ALP rises physiologically for children and teenagers during periods of active growth, as well as for women during the third
trimester of pregnancy.
Marked increases of ALP rate are observed in case of extra-hepatic obstruction (gallstones, tumours…) and bone diseases such as
Paget’s disease and osteogenic bone cancer. PAL activity can also increase moderately in the event of intra-hepatic obstruction,
hepatitis, cirrhosis, or along with rickets, osteomalacia, hyperparathyroidism, healing of bone fractures.